研究兴趣:
张勇博士的主要研究方向是阐述在健康和疾病状态下神经可塑性以及学习和记忆的分子机制。具体运用双光子活体成像技术研究神经元表面AMPA型谷氨酸受体动态,神经元活性(运用遗传编码的钙离子指示剂,如GCamP6),以及神经元内各种信号通路的活性(运用FRET或者单色的信号通路生物传感器,biosensors)对动物行为以及学习和记忆的影响。
代表性科研论文:
1. Zhang Y, Cudmore R, Lin DT, Linden DJ, and Huganir RL. 2015. Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Nat. Neurosci. 18: 402-407.
2. Sharma K, Choi SY, Zhang Y, Nieland T, Long S, Li M, and Huganir RL. 2013. High-throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development. Cell Rep. 5: 1330-1341.
3. Zhang Y, Billington CJ Jr, Pan D, and Neufeld TP. 2006. Drosophila target of rapamycin kinase functions as a multimer. Genetics. 172: 355-362.
4. Pan D, Dong J, Zhang Y, and Gao X. 2004. Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol. 14: 78-85.
5. Zhang Y, Gao X, Saucedo L, Ru B, Edgar B, and Pan D. 2003. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5: 578-581.
6. Gao X#, Zhang Y#, Arrazola P, Hino O, Kobayashi T, Yeung R, Ru B, and Pan D. 2002. Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling. Nat. Cell Biol. 4: 699-704. (#Equal contribution)
实验室网站:
PKU-IDG/McGovern Institute For Brain Research 2013
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