研究兴趣：

杨竞课题组致力于神经免疫调控（neuroimmune regulation）的交叉学科方向。在传统观念中，神经系统和免疫系统是机体内相互独立、行使不同功能的两个系统。但是越来越多的证据表明，神经系统具有调节各个器官或组织内免疫反应的重要作用。神经免疫调控正成为生物医学领域中一个新兴、前沿、热点方向。

课题组跨学科整合全组织三维成像、光/化学遗传学、动物疾病模型及人类临床样本，建立了领先的神经免疫研究平台。课题组已在经典免疫器官天然免疫、肺部2型免疫反应、肠道急性炎症、肿瘤免疫等多个方面取得创新性成果，开拓了不同生理或病理条件下神经免疫调控的全新视角。不仅如此，课题组最新工作探索了神经退行性疾病或代谢类疾病中神经免疫调控的重要功能。这些研究成果将为利用特异性神经信号治疗不同免疫相关疾病提供关键的理论切入点。

代表性科研论文：

Representative Research Papers (*, first author; #, corresponding author):

(1) Liu T, Yang L, Han X, Ding X, Li J, and Yang J#, Local sympathetic innervations modulate the lung innate immune responses. Science Advances. 2020 May 13;6(20):eaay1497.

(2) Wang Q, Liu K, Yang L, Wang H, and Yang J#, BoneClear: Whole-tissue immunolabeling of the intact mouse bones for 3D imaging of neural anatomy and pathology. Cell Research. 2019 Oct;29(10):870-872.

(3) Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, and Yang J#, Panicle-shaped sympathetic architecture in the spleen parenchyma modulates antibacterial innate immunity. Cell Reports. 2019 Jun 25;27(13):3799-3807.

(4) Zhou N, Liu K, Sun Y, Cao Y, and Yang J#, Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein Cell. 2019 Feb;10(2):87-103.

(5) Zhou N and Yang J#, Molecular Mechanism of Wallerian Degeneration. Chinese Bulletin of Life Sciences. 2017 Mar; 29(3): 245-250.

(6) Yang J*, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, and Tessier-Lavigne M, Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15;160(1-2):161-76.

(7) Renier N, Wu Z, Simon DJ, Yang J, Ariel P, and Tessier-Lavigne M, iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.

(8) Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, and Tessier-Lavigne M, Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89.

(9) Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, and Freeman MR, dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4.

(10) Yang J*, Zhao TJ*, Goldstein JL, and Brown MS, Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10750-5.

(11) Yang J*, Brown MS, Liang G, Grishin NV, and Goldstein JL, Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96.

Book Chapters:

(1) Cao Y and Yang J, Whole-Tissue Immunolabeling and 3D Fluorescence Imaging to Visualize Axon Degeneration in the Intact, Unsectioned Mouse Tissues. In: Babetto E. (eds) Axon Degeneration. Methods in Molecular Biology, 2020 Jun 11;2143: 223-232. Humana, New York, NY.

(2) Wang F, Yang J, and He Z, Axon maintenance and degeneration. In: Rubenstein J., Rakic P., Chen B., Kwan K.Y., Kolodkin A., and Anton E. (eds) Cellular Migration and Formation of Axons and Dendrites (Second Edition). Comprehensive Developmental Neuroscience, 2020 Jun 5;217-230. Academic Press, Cambridge, MA.

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